Blending In Vitro & In Vivo Models to Overcome Species Sequence Variation for Preclinical Testing of Human Genetic Targets
Time: 2:45 pm
day: Day One PM
Details:
• Differentiating motor neurons from human stem cells derived from ALS patients
• Creating a model system: implanting differentiated motor neurones into mouse brains
• Utilizing model system to investigate preclinical engagement of candidates against validated human genetic targets
