Aarti Sharma
Company: Regeneron Pharmaceuticals Inc
Job title: Associate Director
Seminars:
Roundtable Discussion: Reinventing the ALS Target Landscape 2:30 pm
More practical and highly interactive breakout roundtables where attendees can crowd-source solutions and share opinions around pre-assigned topic areas: Looking beyond TDP-43: Are there other RNA binding protein dysfunctions involved in sporadic ALS? Are their specific genetic mutations in ALS that could be addressed with RNA editing technologies? What are the most promising microglia and…Read more
day: Day One PM
Novel Humanized Mouse Models of ALS Recapitulate the Human Molecular & Pathological Hallmarks of ALS But Overcome the Artifacts Associated with TDP-43 Over-Expression 10:45 am
Overexpression of TDP-43 leads to aggressive phenotypes and potential artifacts that are not related to ALS Humanized C9orf72 and TDP-43 mouse models show degeneration, TDP-43 mislocalization, aggregation and mis-splicing of TDP-43 targets These models can be used to rapidly screen therapeutics that restore TDP-43 functionRead more
day: Day Two Track A AM
Chair’s Closing Remarks 5:45 pm
day: Day One PM
Chair’s Opening Remarks 7:55 am
day: Conference Day One Morning